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Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications.

Ruslan RustRebecca Z WeberMelanie GeneraliDebora KehlChantal BodenmannDaniela UhrDebora WannerKathrin J ZürcherHirohide SaitoSimon P HoerstrupRoger M NitschChristian Tackenberg
Published in: Journal of translational medicine (2022)
We describe the generation of transgene- and xeno-free NPCs. This simple differentiation protocol combined with the ability of in vivo cell tracking presents a valuable tool to develop safe and effective cell therapies for various brain injuries.
Keyphrases
  • single cell
  • cell therapy
  • stem cells
  • white matter
  • resting state
  • multiple sclerosis
  • diabetic rats
  • bone marrow
  • functional connectivity
  • endothelial cells