Notch signaling in mouse blastocyst development and hatching.

Mariana R BatistaPatrícia DinizAna TorresDaniel MurtaLuís Lopes-da-CostaElisabete Silva

Published in: BMC developmental biology (2020)

Transcription of Notch genes showed a dynamic pattern along blastocyst development and hatching. Data confirmed Notch signaling activity, and lead to the suggestion that Notch canonical signaling may be operating through Notch1, Notch3, Jagged1 and Hes1. Embryo culture supplementation with Jagged1 and Jagged2 unveiled a possible regulatory effect between Jagged1, Cdx2 and blastocyst hatching. Overall, results indicate that a deregulation in Notch signaling, either by its over or under-activation, affects blastocyst development and hatching.

Keyphrases

cell proliferation
pregnant women
big data
gene expression
electronic health record
machine learning
pregnancy outcomes