Alteration in Rab11-mediated endocytic trafficking of LDL receptor contributes to angiotensin II-induced cholesterol accumulation and injury in podocytes.

Jijia HuZijing ZhuZhaowei ChenQian YangWei LiangGuohua Ding

Published in: Cell proliferation (2022)

Rab11 triggers the endocytic trafficking and recycling of LDLR; overactivation of this pathway contributes to Ang II-induced podocyte cholesterol accumulation and injury.

Keyphrases

angiotensin ii
high glucose
low density lipoprotein
endothelial cells
angiotensin converting enzyme
diabetic rats
vascular smooth muscle cells
diabetic nephropathy
oxidative stress
stress induced