Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy.
R DondiE YaghiniKunal TewariL WangF GiuntiniM LoizidouA J MacRobertI M EgglestonPublished in: Organic & biomolecular chemistry (2018)
Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).
Keyphrases
- photodynamic therapy
- drug delivery
- cancer therapy
- fluorescence imaging
- single cell
- coronary artery disease
- percutaneous coronary intervention
- acute coronary syndrome
- structure activity relationship
- acute myocardial infarction
- cell therapy
- antiplatelet therapy
- stem cells
- atrial fibrillation
- st elevation myocardial infarction
- solid state
- ionic liquid
- mesenchymal stem cells
- bone marrow
- quantum dots
- left ventricular