ALS-plus related clinical and genetic study from China.
Cheng ChangQianqian ZhaoPan LiuYanchun YuanZhen LiuYiting HuWanzhen LiXiaorong HouXuxiong TangBin JiaoJifeng GuoLu ShenHong JiangBeisha TangXuewei ZhangJun-Ling WangPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
In summary, ALS-plus patients in China are not rare and show multiple differences from ALS-pure patients in clinical and genetic features. Besides, ALS-cognitive impairment group tends to harbour more ALS-plus syndrome than ALS-cognitive normal group. Our observations correspond with the theory that ALS involves several diseases with different mechanisms and provide clinical validation.