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Don't SUMP it! Utility of PLAG1 immunocytochemistry in basaloid SUMP subcategory.

Monica Sanchez-AvilaYouley TjendraYiqin ZuoRoberto Ruiz-CorderoMonica Garcia-BuitragoMerce JordaCarmen Gomez-FernandezJaylou M Velez Torres
Published in: Cancer cytopathology (2023)
PLAG1 ICC is useful when positive (strong/diffuse) and can be reliably performed on smears and LBC specimens. PLAG1 was positive in most PAs and in a small subset of BCAs. Therefore, in the absence of atypical cytologic features, PLAG1-positive tumors could be diagnosed as benign, with a note favoring PA versus BCA. In contrast, PLAG1-negative/equivocal tumors should remain in the B-SUMP category.
Keyphrases
  • magnetic resonance
  • magnetic resonance imaging
  • fine needle aspiration