Cambiarenes: Single-Step Synthesis and Selective Zwitterion Binding of a Clip-Shaped Macrocycle with a Redox-Active Core.
Riley J PetersenBrett James RozeboomShalisa M OburnNolan J BlytheTanner L RathjeJavier A LunaSteven K KibbyEmily A O'BrienKayleigh G RohrJoshua R CarpenterTaylor L SandersAndrew M JohnsonKristin M HutchinsScott K ShawLeonard R MacGillivrayJay Wm WackerlyPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
A novel macrocyclic host molecule was synthesized that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, it is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine N-oxides based on the electron density of and steric bulk around the anionic oxygen.