Mastitis is the most economically important disease affecting the dairy industry worldwide. Lactobacillus plantarum, an important probiotic with a wide range of applications, has potential anti-inflammatory properties and has become a currently strong candidate for mastitis therapies. In the current study, we evaluated the prevention effect of Lactobacillus plantarum 17-5 on Escherichia coli-induced mastitis in mice. The results showed that pretreatment with L. plantarum 17-5 maintained the integrity of tight junctions; improved inflammatory injury; decreased MPO activity and the mRNA expression levels of IL1β, IL6, and TNFα; and inhibited the NF-κB and MAPK signaling pathways in mice mammary tissue. The results indicated that Lactobacillus plantarum 17-5 had excellent anti-inflammatory activities and could be developed into microecological preparation for clinical use to prevent mastitis.
Keyphrases
- escherichia coli
- signaling pathway
- anti inflammatory
- high fat diet induced
- oxidative stress
- diabetic rats
- pi k akt
- high glucose
- rheumatoid arthritis
- blood brain barrier
- drug induced
- wild type
- type diabetes
- lps induced
- metabolic syndrome
- klebsiella pneumoniae
- cell proliferation
- induced apoptosis
- staphylococcus aureus
- risk assessment
- nuclear factor
- human health
- mass spectrometry
- toll like receptor
- multidrug resistant
- simultaneous determination