Oxy-Alkylation of Allylamines with Unactivated Alkyl Bromides and CO2 via Visible-Light-Driven Palladium Catalysis.
Liang SunJian-Heng YeWen-Jun ZhouXin ZengDa-Gang YuPublished in: Organic letters (2018)
A selective oxy-alkylation of allylamines with unactivated alkyl bromides and CO2 via visible-light-driven palladium catalysis is reported. The commercially available Pd(PPh3)4 is used as the sole catalyst in this three-component reaction. A variety of tertiary, secondary, and primary alkyl bromides undergo reactions to generate important 2-oxazolidinones in high yields and selectivity. The mild reaction conditions, easy scalability, and facile derivatization of products provide great potential for application in organic synthesis and pharmaceutical chemistry.
Keyphrases
- visible light
- reduced graphene oxide
- ms ms
- liquid chromatography tandem mass spectrometry
- ionic liquid
- simultaneous determination
- high performance liquid chromatography
- liquid chromatography
- gas chromatography mass spectrometry
- electron transfer
- human health
- gold nanoparticles
- mass spectrometry
- water soluble
- climate change
- solid phase extraction