Open Thy Lattice Osteoclast, Resorb me!

Published in: The Journal of cell biology (2023)

Osteoclasts degrade bone using Cathepsin K and two metalloproteinases: MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202206121) discover that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts.

Keyphrases

bone loss
cell surface
cell migration
single cell
minimally invasive
bone mineral density
stem cells
mesenchymal stem cells
soft tissue
body composition
low density lipoprotein