Impairment of AMPK-α2 augments detrusor contractions in bladder ischemia.
Jing-Hua YangWanting NiuYedan LiKazem M AzadzoiPublished in: Investigative and clinical urology (2021)
Ischemia induces post-translational modification of AMPK-α2 protein. Impairment of AMPK-α2 may contribute to overactive detrusor contractions and loss of nerve fibers in bladder ischemia. AMPK activators may have therapeutic potential against detrusor overactivity and neurodegeneration in bladder conditions involving ischemia.