A new sequential animal model for infection-related non-unions with segmental bone defect.

Lars HelbigThorsten GuehringNadine TitzeDennis NurjadiRobert SonntagJonas ArmbrusterBritt WildemannGerhard SchmidmaierAlfred Paul GruetznerHolger Freischmidt

Published in: BMC musculoskeletal disorders (2020)

We were able to successfully develop a new two-stage non-union animal model, which reflects a genuine clinical situation of an infection-related non-union model with segmental bone defects. This model could be used to evaluate various therapeutic anti-infectious and osteoinductive strategies in FRIs.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women