The proposed ultrasensitive CL imaging DNA hybridization has high specificity, sensitivity, and reproducibility and could detect and differentiate clinical specimens that carried various carbapenemase genes, suggesting that the method can conveniently be customized for high-throughput detection of the carbapenemase-producing GNB and can be easily adapted for various clinical applications.
Keyphrases
- klebsiella pneumoniae
- label free
- acinetobacter baumannii
- clinical evaluation
- gram negative
- single molecule
- high throughput
- circulating tumor
- bioinformatics analysis
- multidrug resistant
- genome wide
- loop mediated isothermal amplification
- cell free
- nucleic acid
- real time pcr
- high resolution
- gold nanoparticles
- drug resistant
- escherichia coli
- genome wide identification
- pseudomonas aeruginosa
- gene expression
- dna methylation
- mass spectrometry
- circulating tumor cells
- photodynamic therapy
- sensitive detection
- structural basis
- ultrasound guided
- liquid chromatography