Role of Glutaminase 2 in Promoting CD4+ T Cell Production of Interleukin-2 by Supporting Antioxidant Defense in Systemic Lupus Erythematosus.

Ryo HisadaNobuya YoshidaSeo Yeon K OriteMasataka UmedaCatalina BurbanoMarc ScherlingerMichihito KonoSuzanne KrishfieldGeorge C Tsokos

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

Our findings suggest that GLS2 has a crucial role in IL-2 production by CD4+ T cells by supporting antioxidant defense, and they offer a new approach to correcting IL-2 production by T cells in SLE.

Keyphrases

oxidative stress
systemic lupus erythematosus
anti inflammatory
innate immune