Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system.
Camila Franco Batista OliveiraDaniela Pereira AlvesBruna Luiza EmerichSuely Gomes de FigueiredoMarta do Nascimento CordeiroMárcia Helena BorgesMichael RichardsonAdriano Monteiro de Castro PimentaIgor Dimitri Gama DuarteMaria Elena de LimaPublished in: The journal of venomous animals and toxins including tropical diseases (2019)
The antinociceptive effect for PnTx4(5-5) was demonstrated against different rat pain models, i.e. induced by PGE2, carrageenan or glutamate. We suggest that the antinociceptive effect of PnTx4(5-5) may be related to an inhibitory activity on the glutamatergic system.