ADP-ribosyltransferase PARP11 suppresses Zika virus in synergy with PARP12.

Lili LiYueyue ShiSirui LiJunxiao LiuShulong ZuXin XuMeiling GaoNina SunChaohu PanLinan PengGenhong ChengGenhong Cheng

Published in: Cell & bioscience (2021)

We identified ADP-ribosyltransferase PARP11 as an anti-ZIKV ISG and found that it cooperated with PARP12 to enhance ZIKV NS1 and NS3 protein degradation. Our findings have broadened the understanding of the anti-viral function of ADP-ribosyltransferase family members, and provided potential therapeutic targets against viral ZIKV infection.

Keyphrases

zika virus
dengue virus
dna damage
dna repair
aedes aegypti
sars cov
oxidative stress
signaling pathway
risk assessment
small molecule
protein protein
human health