HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis.
Jinxiao LiMan HuNa LiuHuarong LiZhaomin YuQian YanMinfeng ZhouYayuan WangYanjuan SongGuangtao PanFengxia LiangRui ChenPublished in: Journal of experimental & clinical cancer research : CR (2020)
This study illustrates that down-regulation of HDAC3 or TGIF1 or up-regulation of miR-296-3p discourages CRC cell progression and slows down tumor growth, which guides towards a novel direction of CRC treatment.