HDAC3 deteriorates colorectal cancer progression via microRNA-296-3p/TGIF1/TGFβ axis.

Jinxiao LiMan HuNa LiuHuarong LiZhaomin YuQian YanMinfeng ZhouYayuan WangYanjuan SongGuangtao PanFengxia LiangRui Chen

Published in: Journal of experimental & clinical cancer research : CR (2020)

This study illustrates that down-regulation of HDAC3 or TGIF1 or up-regulation of miR-296-3p discourages CRC cell progression and slows down tumor growth, which guides towards a novel direction of CRC treatment.

Keyphrases

histone deacetylase
single cell
cell therapy
transforming growth factor
epithelial mesenchymal transition
bone marrow
mesenchymal stem cells
combination therapy