Clinical and epigenetic features of colorectal cancer patients with somatic POLE proofreading mutations.

Takashi KawaiAkihiro NyuyaYoshiko MoriTakehiro TanakaHiroaki TaniokaKazuya YasuiToshiaki ToshimaFumitaka TaniguchiKunitoshi ShigeyasuYuzo UmedaToshiyoshi FujiwaraMakoto OkawakiYoshiyuki YamaguchiAjay GoelTakeshi Nagasaka

Published in: Clinical epigenetics (2021)

CRC patients with POLE proofreading mutations are rare. Such mutations are observed in younger individuals, and tumours are primarily located in the right colon. Diagnosis occurs at an earlier stage, and distinct epigenetic alterations may be associated with CD8 cell infiltration.

Keyphrases

dna methylation
gene expression
single cell
cell therapy
copy number
mesenchymal stem cells
bone marrow