Reducing tumor invasiveness by ramucirumab and TGF-β receptor kinase inhibitor in a diffuse-type gastric cancer patient-derived cell model.

Song-Yi LeeSeonggyu ByeonJihoon KoSujin HyungIn-Kyoung LeeNoo Li JeonJung Yong HongSeung Tae KimSe Hoon ParkJeeyun Lee

Published in: Cancer medicine (2021)

In this study, we showed TEW-7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse-type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model.

Keyphrases

gas chromatography
low grade
high throughput
cell therapy
transforming growth factor
high glucose
diabetic rats
stem cells
mass spectrometry
oxidative stress
mesenchymal stem cells
drug induced
epithelial mesenchymal transition
binding protein
simultaneous determination