The variability of glycated hemoglobin is associated with renal function decline in patients with type 2 diabetes.
Chia-Lin LeeCheng-Hsu ChenMing-Ju WuShang-Feng TsaiPublished in: Therapeutic advances in chronic disease (2020)
HbA1c variability is an independent risk factor for deterioration of renal function. Even with well-controlled HbA1c levels (<7%), patients with high HbA1c_CV still experienced faster eGFR decline. Early minimization of glycemic variability (before macroalbuminuira) can curb deterioration of renal function. Monitoring and lowering of HbA1c_CV is highly recommended for diabetic care.