Consistency between chromosomal status analysis of biopsied human blastocyst trophectoderm cells and whole blastocyst cells.

Harunori TakahashiKazumasa TakahashiMayumi GotoTakeo HirakawaHisataka HasegawaAkihiro ShitaraTakuya IwasawaKazue TogashiKenichi MakinoHiromitsu ShirasawaHiroshi MiuraWataru SatoYukiyo KumazawaYukihiro Terada

Published in: Reproductive medicine and biology (2021)

Chromosomal status analysis based on TE biopsy does not accurately reflect the chromosomal status of the whole blastocyst. The chromosomal status is usually the same between the TE and remaining blastocyst cells in cases diagnosed as euploid or aneuploid with no mosaicism. However, mosaic blastocysts and those with other types of structural rearrangements have a higher risk of inconsistency, warranting caution during embryo selection.

Keyphrases

induced apoptosis
cell cycle arrest
copy number
endothelial cells
endoplasmic reticulum stress
cell death
oxidative stress
pregnant women
gene expression
genome wide