Influence of cerebral blood flow on volumetric loss related to Alzheimer's disease.
Maria Izaura Sedoguti Scudeler AgnollittoRenata Ferranti LeoniMaria Paula FossJulia PalarettiMarcela CayresVitor PansarimJulio César NatherMaria Clara Zanon ZotinEduardo FerriolliNereida Kilza da Costa LimaAntonio Carlos Dos SantosJulio César MorigutiPublished in: Dementia & neuropsychologia (2023)
In patients with MCI, the reduction of CBF in the left posterior cingulate correlated with gray matter atrophy, as well as the increase of CBF in the right upper temporal pole correlated with an increase in cerebrospinal fluid consequent to the encephalic volumetric reduction associated with atrophy, demonstrating the influence of CBF in AD related brain atrophy. These findings position CBF as a possible vascular biomarker for early-stage AD diagnoses.