Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy.

Changhwan YoonJu LuBang-Jin KimSoo-Jeong ChoJong Hyun KimRyan H MoySandra W RyeomSam S Yoon

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2023)

Patient-derived organoids (PDOs) can serve as personalized in vitro models of patient tumors. In this study, PDOs from locally advanced gastric cancers were able to reliably predict resistance to neoadjuvant chemotherapy.

Keyphrases

neoadjuvant chemotherapy
locally advanced
rectal cancer
squamous cell carcinoma
radiation therapy
phase ii study
sentinel lymph node
lymph node
case report
induced pluripotent stem cells
early stage
open label
squamous cell
double blind