Role of IL-18 in adipose tissue remodeling and metabolic dysfunction.
Jaqueline Pereira LanaMarina Chaves de OliveiraAna Letícia Malheiros SilveiraLetícia Tamie Paiva YamadaKátia Anunciação CostaSimone Vargas da SilvaAgatha de Assis-FerreiraEmmanuel L GautierSébastien DussaudVanessa PinhoMauro Martins TeixeiraGeneviève MarcelinKarine ClementAdaliene Versiani Matos FerreiraPublished in: International journal of obesity (2005) (2024)
IL-18 signaling may control adipose tissue expansion and glucose metabolism, as its absence leads to spontaneous obesity and glucose intolerance in mice. We suggest that resistance to IL-18 signaling may be linked with worse glucose metabolism in humans with obesity.