IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis.

Qi PengBin LiPengli SongRuiyan WangJing JiangXuerui JinJie ShenJingpiao BaoJianbo NiXiao HanGuoyong Hu

Published in: British journal of pharmacology (2024)

We identified the IDH2-NADPH pathway as a novel regulator in protecting against AP via restricting acinar cell ferroptosis. Targeting the pathway and its downstream may shed light on AP treatment.

Keyphrases

transcription factor
cell death
single cell
cell therapy
low grade
reactive oxygen species
stem cells
mesenchymal stem cells
high grade