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Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries.

Andrew B LindenRobert J ClarkeImen HammamiJemma C HopewellYu GuoWilliam N WhiteleyKuang LinIain TurnbullYiping ChenCanqing YuJun LvAlison OfferDerrick BennettRobin G WaltersLiming LiZhengming ChenSarah Parishnull null
Published in: PLoS medicine (2022)
The findings provide support for a causal association of taller adult height with higher risk of cardioembolic stroke and lower risk of other ischemic stroke subtypes in diverse ancestries. Further research is needed to understand the shared biological and physical pathways underlying the associations between height and stroke risks, which could identify potential targets for treatments to prevent stroke.
Keyphrases
  • atrial fibrillation
  • body mass index
  • physical activity
  • mental health
  • cerebral ischemia
  • copy number