The influence of drug properties and host factors on delayed onset of symptoms in drug-induced liver injury.

Andres Gonzalez-JimenezKristin McEuenMinjun Chen Ayako SuzukiMercedes Robles-DiazInmaculada Medina-CalizFernando BessoneNelia HernandezMarco ArreseRaymundo ParanaMaría Isabel LucenaCamilla StephensRaúl J Andrade

Published in: Liver international : official journal of the International Association for the Study of the Liver (2018)

This study demonstrated that delayed onset, a specific DILI phenotype, is explained by complex interactions among drug properties and host factors and provided mechanistic hypotheses for future studies. These findings can help improve the diagnostic capability and causality assessment.

Keyphrases

drug induced
adverse drug
emergency department
physical activity
depressive symptoms