Adipose tissue-derived stem cells prevent fibrosis in murine steatohepatitis by suppressing IL-17-mediated inflammation.

Masatoshi YamatoYoshio SakaiHatsune MochidaKazunori KawaguchiMasayuki TakamuraSoichiro UsuiAkihiro SekiEishiro MizukoshiTaro YamashitaTatsuya YamashitaKousuke IshidaAlessandro NastiHo Thuy Bich TuyenTakuya KomuraKeiko YoshidaTakashi WadaMasao HondaShuichi Kaneko

Published in: Journal of gastroenterology and hepatology (2019)

ADSCs treatment prevented progression of NASH fibrosis by suppressing IL-17-mediated inflammation, which was associated with HSCs activation.

Keyphrases

stem cells
adipose tissue
oxidative stress
liver fibrosis
type diabetes
cell therapy
metabolic syndrome
skeletal muscle
mesenchymal stem cells