Aging, Diabetes, Obesity, and Cognitive Decline: A Population-Based Study.
Mary GanguliJoanne C BeerJoseph M ZmudaChristopher M RyanKevin J SullivanChung-Chou H ChangR Harsha RaoPublished in: Journal of the American Geriatrics Society (2020)
Our population-based data suggest that, in individuals younger than 88 years with central obesity, even modest degrees of hyperglycemia might independently predispose to faster cognitive decline. In contrast, among those younger than 87 years without central obesity, adiponectin may be a novel independent risk factor for cognitive decline. J Am Geriatr Soc 68:991-998, 2020.
Keyphrases
- magnetic resonance imaging
- cognitive decline
- insulin resistance
- mild cognitive impairment
- metabolic syndrome
- type diabetes
- weight loss
- high fat diet induced
- weight gain
- magnetic resonance
- adipose tissue
- skeletal muscle
- glycemic control
- electronic health record
- machine learning
- body mass index
- big data
- oxidative stress