Longitudinal analysis of host protein serum signatures of treatment and recovery in pulmonary tuberculosis.

Samantha M Powell Leah G JarsbergErin L M ZionceLindsey N Anderson Marina A GritsenkoPayam NahidJon M Jacobs

Published in: PloS one (2024)

Previous proteome studies have primarily focused on the 8-week timepoint in relation to culture conversion status. While this study confirms previous observations, it also highlights some differences. The inclusion of additional end of treatment and post-treatment time points offers a more comprehensive assessment of treatment progression within the serum proteome. Examining the expression dynamics at these later time periods will help in the investigation of relapse patients and has provided indicative markers of response and recovery.

Keyphrases

pulmonary tuberculosis
gene expression
end stage renal disease
mycobacterium tuberculosis
newly diagnosed
combination therapy
peritoneal dialysis
study protocol
prognostic factors
patient reported outcomes