Positioning risankizumab in the treatment algorithm of moderate-to-severe Crohn's disease.
Francesca LusettiFerdinando D'AmicoMariangela AlloccaFederica FurfaroAlessandra ZilliGionata FiorinoTommaso Lorenzo ParigiSimona RadiceLaurent Peyrin-BirouletSilvio DanesePublished in: Immunotherapy (2024)
Risankizumab is a humanized monoclonal antibody that inhibits the p19 subunit of IL-23 cytokine. Recently it has been approved for the treatment of patients with moderate-to-severe Crohn's disease (CD). We conducted a scoping review to summarize the available data on risankizumab and to define its positioning in the treatment algorithm of CD. Pubmed, Embase and Scopus databases were searched up to Oct 31, 2023 to identify studies reporting efficacy and safety data of risankizumab in patients with CD. Risankizumab is an effective and safe drug for the management of patients with moderate-to-severe CD. It could be used as first-line therapy in biologic-naive patients and in patients who have previously failed other biological therapies.
Keyphrases
- end stage renal disease
- monoclonal antibody
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- early onset
- deep learning
- high intensity
- rheumatoid arthritis
- electronic health record
- stem cells
- patient reported outcomes
- optical coherence tomography
- drug induced
- combination therapy
- mesenchymal stem cells
- protein kinase
- drug administration