Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression.

Christopher GrothLudovica ArpinatiMerav E ShaulNina WinklerKlara DiesterNicolas GengenbacherRebekka BitschIhor ArkhypovSamantha LasserVera PetrovaHellmut G AugustinPeter AltevogtJochen Sven Utikal Zvi G Fridlender Viktor Umansky

Published in: Cancers (2021)

We provide evidence for the tumor-promoting properties of PMN-MDSC as well as for the anti-tumor effects upon their targeting in melanoma bearing mice.

Keyphrases

induced apoptosis
cell cycle arrest
skin cancer
cancer therapy
high fat diet induced
basal cell carcinoma
endoplasmic reticulum stress
signaling pathway
oxidative stress
type diabetes
drug delivery
skeletal muscle