ECDD-S16 targets vacuolar ATPase: A potential inhibitor compound for pyroptosis-induced inflammation.
Peeraya EkchariyawatRattatammanoon SaengfakSucharat SanongkietThanapon CharoenwongpaiboonSuphasuta KhongpraphanSupaporn MalaChularat LuangjindaratBumrung MunyooNapason ChabangSitthivut CharoensutthivarakulSuparerk BorwornpinyoPatoomratana TuchindaMarisa PonpuakMatsayapan PudlaPongsak UtaisincharoenPublished in: PloS one (2023)
Our findings indicate the potential of ECDD-S16 for inhibiting pyroptosis and prove that vacuolar H+ ATPase is essential for pyroptosis induced by TLR ligands.