ECDD-S16 targets vacuolar ATPase: A potential inhibitor compound for pyroptosis-induced inflammation.

Peeraya EkchariyawatRattatammanoon SaengfakSucharat SanongkietThanapon CharoenwongpaiboonSuphasuta KhongpraphanSupaporn MalaChularat LuangjindaratBumrung MunyooNapason ChabangSitthivut CharoensutthivarakulSuparerk BorwornpinyoPatoomratana TuchindaMarisa PonpuakMatsayapan PudlaPongsak Utaisincharoen

Published in: PloS one (2023)

Our findings indicate the potential of ECDD-S16 for inhibiting pyroptosis and prove that vacuolar H+ ATPase is essential for pyroptosis induced by TLR ligands.

Keyphrases

nlrp inflammasome
oxidative stress
toll like receptor
inflammatory response
immune response
diabetic rats
high glucose
signaling pathway
human health
endoplasmic reticulum