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ECDD-S16 targets vacuolar ATPase: A potential inhibitor compound for pyroptosis-induced inflammation.

Peeraya EkchariyawatRattatammanoon SaengfakSucharat SanongkietThanapon CharoenwongpaiboonSuphasuta KhongpraphanSupaporn MalaChularat LuangjindaratBumrung MunyooNapason ChabangSitthivut CharoensutthivarakulSuparerk BorwornpinyoPatoomratana TuchindaMarisa PonpuakMatsayapan PudlaPongsak Utaisincharoen
Published in: PloS one (2023)
Our findings indicate the potential of ECDD-S16 for inhibiting pyroptosis and prove that vacuolar H+ ATPase is essential for pyroptosis induced by TLR ligands.
Keyphrases
  • nlrp inflammasome
  • oxidative stress
  • toll like receptor
  • inflammatory response
  • immune response
  • diabetic rats
  • high glucose
  • signaling pathway
  • human health
  • endoplasmic reticulum