Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.
Yann Le GuenValerio NapolioniMichael E BelloyEric YuLynne KrohnJennifer A RuskeyZiv Gan OrGabriel KennedySarah J EgerMichael D GreiciusPublished in: Annals of neurology (2021)
We report the first XWAS of PD and identify 2 genome-wide significant loci. The rs28602900 association was replicated in an independent PD dataset and showed concordant effects in its association with putamen volume. Critically, rs26802900 is a significant eQTL of RPL10. These results support a role for ribosomal proteins in PD pathogenesis and show that the X-chromosome contributes to PD genetic risk. ANN NEUROL 2021;90:22-34.