Lactoferrin Reduces Necrotizing Enterocolitis Severity by Upregulating Intestinal Epithelial Proliferation.

Jia LiuHaitao ZhuBo LiShaiya C RobinsonCarol LeeJoshua S O'ConnellEdoardo BindiShan ZhengPhilip M ShermanAgostino Pierro

Published in: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie (2019)

Lactoferrin administration reduces the intestinal injury in experimental NEC by downregulating inflammation and upregulating cell proliferation. This beneficial effect of lactoferrin in stimulating cell proliferation is mediated by the Wnt pathway. This experimental study provides insights on the mechanism of action of lactoferrin in NEC and the role of lactoferrin in enteral feeding.

Keyphrases

cell proliferation
recombinant human
cell cycle
stem cells
oxidative stress
preterm infants