Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth muscle cells via integrin-β1/ERK signaling pathway.

Haibo YuChunyu ZhouDayong HuChangbin LiQiang WangWen XueAi Peng

Published in: Clinical and experimental nephrology (2022)

We first demonstrated that ITGβ1/ERK signaling pathway mediated abnormal focal adhesion, migration and proliferation of vascular smooth muscle cells stimulated by IS. ITGβ1/ERK signaling may serve as a novel therapeutic target for CKD-CVD.

Keyphrases

signaling pathway
vascular smooth muscle cells
pi k akt
angiotensin ii
induced apoptosis
epithelial mesenchymal transition
escherichia coli
chronic kidney disease
oxidative stress
cell adhesion
cystic fibrosis