miRNA-seq identification and clinical validation of CD138+ and circulating miR-25 in treatment response of multiple myeloma.
Maria-Alexandra PapadimitriouKonstantinos SoureasAristea-Maria PapanotaPanagiotis TsiakanikasPanagiotis G AdamopoulosIoannis Ntanasis-StathopoulosPanagiotis MalandrakisMaria GavriatopoulouDiamantis C SiderisEfstathios KastritisMargaritis AvgerisMeletios-Athanasios DimopoulosEvangelos TerposAndreas ScorilasPublished in: Journal of translational medicine (2023)
Our study identified miR-25 overexpression as a powerful independent predictor of poor treatment outcome and post-treatment progression, aiding towards modern non-invasive disease prognosis and personalized treatment decisions.