The obesity paradox in metastatic castration-resistant prostate cancer.
Alberto MartiniQainat N ShahNikhil WaingankarJohn P SfakianosChe-Kai TsaoAndrea NecchiFrancesco MontorsiEmily Jane GallagherMatthew D GalskyPublished in: Prostate cancer and prostatic diseases (2021)
Obese patients with mCRPC had better cancer-specific and overall survival as compared to overweight and normal weight patients. The protective effect of BMI was not related to receiving higher chemotherapy doses. Further studies aimed at elucidating the biological mechanism behind this effect are warranted.
Keyphrases
- weight loss
- obese patients
- weight gain
- bariatric surgery
- end stage renal disease
- body mass index
- roux en y gastric bypass
- gastric bypass
- ejection fraction
- physical activity
- squamous cell carcinoma
- metabolic syndrome
- type diabetes
- chronic kidney disease
- small cell lung cancer
- papillary thyroid
- insulin resistance
- peritoneal dialysis
- radiation therapy
- locally advanced
- young adults
- adipose tissue
- lymph node metastasis
- patient reported
- drug induced