Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy.

Sean Murphy Sharif Rahmy Dailin Gan Guoqiang Liu Yini Zhu Maxim Manyak Loan Duong Jianping He James H Schofield Zachary T Schafer Jun Li Xuemin Lu Xin Lu

Published in: Cancer research (2024)

Optimized cyclic ketogenic diet and 1,3-butanediol supplementation regimens enhance the efficacy of immune checkpoint blockade in prostate cancer through epigenetic and immune modulations, providing dietary interventions to sensitize tumors to immunotherapy.

Keyphrases

prostate cancer
physical activity
radical prostatectomy
dna methylation
weight loss
gene expression
stem cells
mesenchymal stem cells