Cramp-Fasciculation Syndrome Associated with Natural and Added Chemicals in Popular Food Items.
Emmeline LagrangeJean-Paul VernouxCelia ChambonWilliam CamuPeter S SpencerPublished in: Foods (Basel, Switzerland) (2024)
Cramp-fasciculation syndrome (CFS) is a rare and benign neuromuscular disorder that may initially masquerade as motor neuron disease/amyotrophic lateral sclerosis. While CFS may have a familial disposition, we report on cases associated with high consumption of popular food items. One set of patients reversibly experienced acute onset of headache, flushing, muscle stiffness and fasciculations following the consumption of umami-flavored food containing a large concentration of monosodium glutamate. A second group of patients consuming food derived from lupin seed developed acute cholinergic toxicity, CFS, and, with chronic intake, significant, self-limiting, but incompletely reversible upper and lower motor neuron deficits. While these cases may improve our knowledge about the possible causes of CFS, our series also demonstrates that excessive consumption of some popular foods is not harmless. This warrants further research on their safety at all stages of human development from a neurological point of view.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- amyotrophic lateral sclerosis
- liver failure
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- traumatic brain injury
- skeletal muscle
- human health
- blood brain barrier
- physical activity
- oxidative stress
- patient reported outcomes
- case report
- weight gain
- aortic dissection
- weight loss
- acute respiratory distress syndrome
- mechanical ventilation