Genomic insights into in-ICU emergence of last-resort antimicrobial resistance in a rare, carbapenem resistant, ST16 Klebsiella pneumoniae strain from Jodhpur, India.
Ardhendu ChakraborttyAastha KapoorTamal DeySharvika Subodh KhochareLavanya AroraVibhor TakVijaya Lakshmi NagPradeep Kumar BhatiaManoharan ShankarPublished in: Journal of global antimicrobial resistance (2024)
BC16 was a colistin resistant derivative of U23, which evolved colistin resistance by an IS5-mediated disruption of the mgrB locus, likely during treatment of the index patient with colistin in the ICU. The strains belong to a rare subtype of ST16 with unique capsular and O-antigen types underscoring the utility of genomic surveillance networks and open-access genomic surveillance data in tracking problem clones.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- antimicrobial resistance
- multidrug resistant
- copy number
- intensive care unit
- public health
- acinetobacter baumannii
- gram negative
- drug resistant
- mechanical ventilation
- case report
- electronic health record
- big data
- gene expression
- cystic fibrosis
- dna methylation
- acute respiratory distress syndrome