Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury.

Xudong ChenShuang LinShanshan DaiJibo HanPeiren ShanWeiqi WangZhouqing HuangBozhi YeWeijian Huang

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)

In summary, TMZ alleviated pyroptosis induced by myocardial I/R injury through the TLR4/MyD88/NF-κB/NLRP3 inflammasome pathway. Therefore, TMZ represents an alternative treatment for myocardial I/R injury.

Keyphrases

nlrp inflammasome
left ventricular
toll like receptor
signaling pathway
nuclear factor
oxidative stress
lps induced
heart failure
pi k akt
atrial fibrillation
smoking cessation