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Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes.

Rebecca C WyattWilliam A HagopianBart O RoepKashyap A PatelBrittany ResnickRebecca DobbsMichelle Hudsonnull nullElisa De FrancoSian EllardSarah E FlanaganAndrew T HattersleyRichard D OramMatthew B Johnson
Published in: Diabetologia (2022)
Our data support the hypothesis that beta cell stress/dysfunction alone does not lead to the production of islet autoantibodies, even in the context of high-risk HLA types. This suggests that additional factors are required to trigger an autoimmune response towards beta cells.
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