USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.
Arishya SharmaTurkeya AlswillahKamini SinghPayel ChatterjeeBelinda WillardMonica VenereMatthew K SummersAlexandru AlmasanPublished in: Autophagy (2018)
ATG7: autophagy related 7; CQ: chloroquine; DDR: DNA damage response; DUB: deubiquitinase; HR: homologous recombination; IR: ionizing radiation; IRIF: ionizing radiation-induced foci; LAMP2: lysosomal associated membrane protein 2; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MIU1: motif interacting with ubiquitin; NHEJ: non homologous end-joining; PCa: prostate cancer; TP53BP1/53BP1: tumor protein p53 binding protein 1; RNF168: ring finger protein 168; SQSTM1/p62 sequestosome 1; γH2AFX/γH2AX: H2A histone family member X: phosphorylated, UBA: ubiquitin-associated; Ub: ubiquitin; Ubn: ubiquitination; USP14: ubiquitin specific peptidase 14.
Keyphrases
- dna repair
- dna damage response
- dna damage
- binding protein
- prostate cancer
- small molecule
- oxidative stress
- protein protein
- simultaneous determination
- diabetic rats
- cell death
- dna methylation
- radical prostatectomy
- high glucose
- amino acid
- endoplasmic reticulum stress
- signaling pathway
- protein kinase
- plasmodium falciparum