Pain catastrophizing is associated with the Val66Met polymorphism of the brain-derived neurotrophic factor in fibromyalgia.

Camila Fernanda da Silveira AlvesWolnei CaumoJoana Morez SilvestriMaxciel ZorteaVinicius Souza Dos SantosDayane Favarin CardosoAndrea RegnerAlessandra Hübner de SouzaDaniel Simon

Published in: Advances in rheumatology (London, England) (2020)

The findings show an association of BDNF Val66Met polymorphism with pain catastrophizing in FM, which opens new avenues to comprehend the interplay between molecular genetic characteristics and neuroplasticity mechanisms underpinning FM.

Keyphrases

chronic pain
pain management
tyrosine kinase
neuropathic pain
genome wide
stress induced
single molecule