Circulating gluten-specific, but not CMV-specific, CD39+ regulatory T cells have an oligoclonal TCR repertoire.
Laura CookCynthia Mee Ling MunierNabila SeddikiMelinda Y HardyRobert P AndersonJohn ZaundersJason A Tye-DinAnthony D KelleherDavid van BockelPublished in: Clinical & translational immunology (2020)
This is the first assessment of the TCR repertoire within circulating human Tregs specific for foreign antigen. These data enhance our understanding of antigen-specific CD4+ responses in the settings of chronic inflammation and infection and may help guide immunomonitoring strategies for CD4+ T cell-based therapies, particularly for coeliac disease.