Multidimensional analysis of the host response reveals prognostic and pathogen-driven immune subtypes among adults with sepsis in Uganda.

Matthew J CummingsBarnabas BakamutumahoAdam PriceNicholas OworJohn KayiwaJoyce NamulondoTimothy ByaruhangaMoses MuwangaChristopher NserekoStephen SameroffRafal TokarzWai WongShivang S ShahMichelle H LarsenW Ian LipkinJulius J LutwamaMax R O'Donnell

Published in: Critical care (London, England) (2022)

Our results highlight unique host- and pathogen-driven features of sepsis immunopathology in sub-Saharan Africa, including the importance of severe HIV-associated tuberculosis, and reinforce the need to develop more biologically-informed treatment strategies in the region, particularly those incorporating immunomodulation.

Keyphrases

septic shock
acute kidney injury
hiv aids
intensive care unit
antiretroviral therapy
candida albicans
hiv positive
hiv infected
human immunodeficiency virus
mycobacterium tuberculosis
hepatitis c virus
early onset
south africa
men who have sex with men