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Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A.
Xueming Li
Fenglian Zhang
Yu Ke
Hongmin Liu
Zhenbo Hu
Liuya Wei
Published in:
Recent patents on anti-cancer drug discovery (2024)
Our results suggest that JOA may be considered a promising anti-leukemia compound to develop to surmount the differentiation block in AL patients.
Keyphrases
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induced apoptosis
cell cycle arrest
acute myeloid leukemia
endoplasmic reticulum stress
bone marrow
atrial fibrillation
prognostic factors
signaling pathway
protein protein