Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort).
Margherita DoriaSonia ZicariNicola CotugnoSara Domínguez-RodríguezAlessandra RuggieroGiuseppe R PascucciAlfredo TagarroPablo RojoEleni NastouliKathleen GärtnerMark CameronBrian RichardsonCaroline FosterSion L WilliamsStefano RinaldiAnita De RossiCarlo GiaquintoPaolo RossiSavita PahwaPaolo Palmanull nullPublished in: Journal of the International AIDS Society (2021)
We show that early initiation of ART during infancy preserves the NK compartment and is associated with lower HIV-1 reservoir. Such condition persists over adolescence due to long-term viral control achieved through effective ART.