Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation.

Satoshi YanagidaMichael S AnglesioTayyebeh M NazeranAmy LumMomoko InoueYasushi IidaHirokuni TakanoTakashi NikaidoAikou OkamotoDavid G Huntsman

Published in: PloS one (2017)

This report describes the preservation of heterozygous c.402C>G FOXL2 mutation in recurrent aGCTs. This finding adds further credence to the concept that the c.402C>G FOXL2 mutation is oncogenic and integral to this disease.

Keyphrases

early onset
single cell
transcription factor
cell therapy
stem cells
adipose tissue
skeletal muscle